- Syndrome involving damage to the following nerves
- Oculomotor nerve (III)
- Trochlear nerve (IV)
- Ophthalmic division of the trigeminal nerve (V1)
- Abducens nerve (VI)
- In contrast to the orbital apex syndrome, the optic nerve is spared in SOF lesions
- Anatomically very close together – often SOF and OAS may involve into each other temporally
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