• Syndrome involving damage to the following nerves
    • Oculomotor nerve (III)
    • Trochlear nerve (IV)
    • Ophthalmic division of the trigeminal nerve (V1)
    • Abducens nerve (VI)
  • In contrast to the orbital apex syndrome, the optic nerve is spared in SOF lesions
  • Anatomically very close together – often SOF and OAS may involve into each other temporally