Jaundice

Differential diagnosis

• Pre-hepatic
  • Congenital
    • Gilbert’s syndrome
    • Crigler-Najjar syndrome
  • Congenital red cell defects
    • Hereditary spherocytosis
    • Hereditary elliptocytosis
    • Glucose-6-phosphate deficiency
  • Haemoglobinopathies
    • Sickle cell disease
    • α thalassaemia
    • β thalassaemia
  • Acquired
    • Malaria
    • Autoimmune haemolytic anaemia
    • ABO incompatible blood transfusion
• Hepatic
  • Infectious
    • Hepatitis A
    • Hepatitis B
    • Hepatitis C
    • Epstein-Barr virus
    • Cytomegalovirus
    • Leptospirosis
  • Inflammatory
    • Autoimmune hepatitis
  • Neoplastic
    • Hepatocellular carcinoma
    • Metastatic carcinoma
  • Drugs
    • Paracetamol
    • Isoniazid
    • Halothane
    • Alcohol
  • Metabolic
    • Non-alcoholic steatohepatitis
    • Haemochromatosis
    • Wilson’s disease
• Post-hepatic
  • Choledocholithiasis
  • Acute cholangitis
  • Inflammatory
    • Primary biliary cirrhosis
    • Primary sclerosing cholangitis
  • Chronic pancreatitis
  • Neoplastic
    • Head of pancreas tumour
    • Cholangiocarcinoma