Approach to Weight Gain

Differential diagnosis

• Endocrine
  • Diabetes
  • Hypothyroidism
  • Cushing’s syndrome
  • Acromegaly
  • Insulinoma – MEN1
  • Polycystic ovarian syndrome
• Fluid retention
  • Ascites from underlying malignancy
  • Nephrotic syndrome
  • Congestive cardiac failure
  • Liver failure
• Duodenal ulcer
• Drugs
  • Sulphonylureas
  • Antipsychotics
  • Oral contraceptive pill
  • Traditional Chinese medicines
  • Antiretroviral therapy
  • Steroids
  • Valproate
• Pregnancy
• Psychological
  • Depression
  • Bulimia