Bite cells are RBCs with irregular, “punched-out” membranes which result from removal of denatured haemoglobin by macrophages in the spleen. Blister cells have a similar appearance, except that there is a residual rim of RBC cytoplasm. They result from oxidative haemolysis.
Peripheral blood film from a patient with oxidative haemolysis showing a bite cell.
Peripheral blood film from a patient with oxidative haemolysis showing a blister cell. Note the thin rim of red cell membrane surrounding the blister (red arrow).
Peripheral blood film from a patient with oxidative haemolysis showing bite cells (red arrows).
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